9 位基础科学奖章得主领衔主讲基础科学报告

2026基础科学奖章得主成就及简介

8月10日至12日，9 位基础科学奖章得主：克莱尔·瓦赞（Claire Voisin）、姚鸿泽（Horng-Tzer Yau）、张寿武（Shouwu Zhang）、刘若微（Andrea J. Liu）、王贻芳（Yifang Wang）、文小刚（Xiao-Gang Wen）、鲍哲南（Zhenan Bao）、庄小威（Xiaowei Zhuang）和张锋（Zhang Feng）将在北京雁栖湖应用数学研究院A2报告厅带来9场基础科学报告，系统阐释基础科学领域的前沿探索成果。数学领域聚焦随机矩阵理论、代数簇零点循环、椭圆曲线与L函数等经典理论的当代革新与跨世纪数学进展；物理领域围绕拓扑序、新型对称理论、希格斯粒子与中微子物理展开探索，深挖粒子物理与基础物理的未来发展方向；工程与材料领域展示了可调物质体系、仿生电子皮肤、神经传感植入器件等前沿技术创新；生命科学领域则聚焦微生物资源挖掘、新型基因编辑系统、空间单细胞基因组学技术，为生命机制解析与生物医药创新提供全新路径。

9位报告嘉宾均为全球基础科学各细分领域的领军学者，学术成果享誉国际、引领学科发展前沿。系列报告立足基础科学本源，既回溯经典理论的迭代演进，也聚焦新兴交叉学科的突破性进展，贯通数理基础、物质科学、工程应用、生命科学四大核心板块，生动呈现现代基础科学多元融合、纵深发展的发展态势，为海内外科研工作者与青年学子搭建高端前沿的国际学术交流平台，推动基础科学前沿思想交汇碰撞，促进跨学科深度融合与原创性创新发展。

时间：

8月10日（星期一）| 上午09:40-10:40

地点：

BIMSA-A2 报告厅

题目：

Tunable Matter

摘要：

In 1972 Phil Andersen articulated the motto of condensed matter physics as “More is different.” However, for most condensed matter systems many more is quite similar to more. Here I argue for a class of condensed matter, “tunable matter,” in which many more is more different—the behaviors of more and of many more can be quite different. A familiar example of tunable matter is the brain, whose cognitive capabilities increase as size increases from 302 neurons (C. Elegans) to a million neurons (honeybees) to 100 billion neurons (humans). Tunable matter extends far beyond the Hopfield model, which exemplifies this behavior. Indeed, I propose that tunable matter provides a unifying conceptual framework for understanding emergent collective function in a wide class of biological systems.

时间：

8月10日（星期一）| 上午10:50-11:50

地点：

BIMSA-A2 报告厅

题目：

Exploration of Biological Diversity

摘要：

Many powerful molecular biology tools have their origin in nature, and, often, microbial life. From restriction enzymes to CRISPR-Cas9, microbes utilize a diverse array of systems to get ahead evolutionarily. We are interested in exploring this natural diversity through bioinformatics, biochemical, and molecular work to better understand the fundamental ways in which living organisms sense and respond to their environment and ultimately to harness these systems to improve human health. Building on our demonstration that Cas9 can be repurposed for precision genome editing in mammalian cells, we began looking for novel CRISPR-Cas systems that may have other useful properties. This led to the discovery of several new CRISPR systems, including the CRISPR-Cas13 family that target RNA, rather than DNA. We developed a toolbox for RNA modulation based on Cas13, including methods for precision base editing. We are expanding our biodiscovery efforts to search for new microbial proteins that may be adapted for applications beyond genome and transcriptome modulation, capitalizing on the growing volume of microbial genomic sequences and building on our bioengineering expertise. We are particularly interested in identifying new therapeutic modalities and vehicles for delivering cellular and molecular cargo. We hope that this combination of tools and delivery modes will accelerate basic research into human disease and open up new therapeutic possibilities.

时间：

8月11日（星期二）| 上午08:30-09:30

地点：

BIMSA-A2 报告厅

题目：

Points and zero-cycles of algebraic varieties

摘要：

Given an algebraic variety X defined over a field K, the closed points of X are defined over K if K is algebraically closed, and over a finite extension of K otherwise. In order to study them, and the corresponding finite extensions, it is useful to introduce the Chow group of zero-cycles of X. When the field is the field of complex numbers, this Chow group contains a lot of information on the global geometry of X, in particular it controls the holomorphic forms on X. This Chow group is trivial when X is a Fano variety over the complex numbers, but is very interesting to study in the case of a Fano variety over a nonalgebraically closed field and it can be used to study rationality questions. I will discuss boundedness/unboundedness for this Chow group, that parallels the notion of infinite dimensionality developed by Mumford in the setting of varieties defined over the complex numbers.

时间：

8月11日（星期二）| 上午09:40-10:40

地点：

BIMSA-A2 报告厅

题目：

From Topological Order to a Beyond-Group Theory of Symmetry

摘要：

Symmetry is one of the central ideas of physics. It helps explain why materials have their universal properties, why fundamental forces act in particular ways, and why the laws of nature are so beautifully organized. For more than a century, physicists have described symmetry using the mathematics of groups: rotations, reflections, and other transformations that leave a system unchanged. This picture has been enormously successful.

But it is not the full story.

In this talk, I will describe a new and much richer view of symmetry that has emerged in recent years, where symmetry is not just a fixed transformation acting on matter. Instead, it is determined by the set of allowed local operations. Once symmetry is understood in this way, striking new possibilities appear: symmetries that act on strings and membranes rather than particles, symmetries that cannot be confined to a subsystem, and symmetries that cannot even be reversed.

These new symmetries are not isolated curiosities. They obey elegant rules of fusion and braiding, closely related to the structure of topological order. This leads to a remarkable idea: the symmetries are the boundary manifestation, or shadow, of topological order in one higher dimension.

Since symmetry lies at the foundation of so much of physics, a new understanding of symmetry may transform the subject at its roots. I will explain how this idea reshapes our picture of phases of matter, phase transitions, and quantum field theories -- and why it may mark the beginning of a new chapter in fundamental physics.

时间：

8月11日（星期二）| 上午10:50-11:50

地点：

BIMSA-A2 报告厅

题目：

From Electronics Skin to NeuroString

摘要：

Skin-inspired electronics aim to replicate the sensing and signal processing functions of human skin for applications in robotics and healthcare. In this talk, I first discuss realizing electronic skin – an electronic sensing system that mimics the human sense of touch through distributed sensor arrays and biologically inspired signal encoding. We develop high-density tactile sensors capable of capturing pressure, temperature, and dynamic contact across large areas, enabling spatially resolved perception. Beyond signal acquisition, we implement spike-based encoding strategies that transform continuous tactile outputs into spike-train signals, allowing efficient transmission and processing of sensory information.

These electronic skin systems are applied to robotic platforms to enhance dexterous manipulation and provide rich tactile feedback. Building on this foundation, we extend the concept to fiber-based, implantable devices, termed “NeuroString,” designed for minimally invasive interfacing with tissue. These platforms enable multiplexed sensing of physiological and chemical signals within the body. Together, this work outlines a pathway from biomimetic electronic skin to implantable bioelectronic systems, bridging external sensing and internal physiological monitoring for next-generation human–machine interfaces.

时间：

8月12日（星期三）| 上午08:30-09:30

地点：

BIMSA-A2 报告厅

题目：

From Euclid to Gross--Zagier: A Mathematical Journey Across Two Millennia

摘要：

This lecture traces two mathematical developments that evolved largely independently over nearly two thousand years. One begins with Euclid's parametrization of right triangles and culminates in the arithmetic of elliptic curves and Heegner points. The other starts with Euler's and Dirichlet's work on prime numbers and leads to the theory of L-functions and their special values. The Gross–Zagier formula reveals a remarkable connection between these two worlds by expressing the arithmetic height of a Heegner point as the central derivative of an L-function. I will also describe some of its arithmetic applications and its far-reaching generalizations to Shimura curves and Shimura varieties. The story illustrates a recurring theme in mathematics: ideas developed in distant areas, often centuries apart, can ultimately converge to illuminate the same arithmetic phenomena.

时间：

8月12日（星期三）| 上午09:40-10:40

地点：

BIMSA-A2 报告厅

题目：

Higgs and Neutrinos: Portal to the Future of Particle Physics

摘要：

After the discovery of Higgs, the Standard Model (SM) is basically completed and particle physics is now at a turning point. On the one hand, SM is just an effective theory at current energy scale with a number of questions not yet answered. On the other hand, experimental evidence beyond the SM have been observed. It is commonly believed that a further understanding of physics at higher energies or deeper levels is needed, to be guided by more experimental discoveries. For such a purpose, Higgs and Neutrinos are the two main portals. I will describe our efforts along these two directions. One is based on the Jiangmen Underground Neutrino Observatory (JUNO) which just started the data taking last year. Another one is the Circular Electron-Positron Collider (CEPC) with a circumference of 100km. After 12 years efforts, CEPC is almost ready for construction. I will describe its design and R&D achievements.

时间：

8月12日（星期三）| 上午10:50-11:50

地点：

BIMSA-A2 报告厅

题目：

Spatially resolved single-cell genomics and functional genomics

摘要：

Cell and tissue functions arise from coordinated activities of thousands of genes expressed in numerous different types of cells. Understanding the functions of cells and tissues thus requires imaging at the genome scale, which will advance our understanding in many areas of biology, ranging from the regulation of gene expression in cells to the diversity, organization, and functions of cells in complex tissues. We developed a single-cell genome-scale imaging method, multiplexed error-robust fluorescence in situ hybridization (MERFISH), which enables spatially resolved single-cell transcriptomics, epigenomics, 3D genomics, and functional genomics. The ability of MERFISH to perform single-cell transcriptomic profiling in intact tissues allows the identification, spatial mapping, and functional investigation of distinct cell types in intact tissues. Spatial epigenomics and 3D-genomics additionally provide insights into the gene regulatory mechanisms that give rise to the distinct cell types. MERFISH-based functional genomics further allows genotype-phenotype mapping of cells in vivo, providing a high-throughput approach to investigate molecular mechanisms of cell and tissue functions. In this talk, I will describe the MERFISH technology and its applications, with a focus on the molecular, spatial, and functional organizations of distinct cell types in the brain and genetic regulators of liver functions.

*本文转载于北京雁栖湖应用数学研究院